Human Cell Tropism and Innate Immune System Interactions of Human Respiratory Coronavirus EMC Compared to Those of Severe Acute Respiratory Syndrome Coronavirus
Identifieur interne : 001930 ( Main/Exploration ); précédent : 001929; suivant : 001931Human Cell Tropism and Innate Immune System Interactions of Human Respiratory Coronavirus EMC Compared to Those of Severe Acute Respiratory Syndrome Coronavirus
Auteurs : Florian Zielecki ; Michaela Weber ; Markus Eickmann ; Larissa Spiegelberg ; Ali Moh Zaki ; Mikhail Matrosovich ; Stephan Becker ; Friedemann WeberSource :
- Journal of Virology [ 0022-538X ] ; 2013.
Descripteurs français
- KwdFr :
- Animaux, Coronavirus (immunologie), Coronavirus (physiologie), Facteur-3 de régulation d'interféron (immunologie), Humains, Immunité innée, Infections à coronavirus (immunologie), Infections à coronavirus (virologie), Interféron de type I (immunologie), Lignée cellulaire, Primates, Réplication virale, Syndrome respiratoire aigu sévère (immunologie), Syndrome respiratoire aigu sévère (virologie), Tropisme viral, Virus du SRAS (immunologie), Virus du SRAS (physiologie).
- MESH :
- immunologie : Coronavirus, Facteur-3 de régulation d'interféron, Infections à coronavirus, Interféron de type I, Syndrome respiratoire aigu sévère, Virus du SRAS.
- physiologie : Coronavirus, Virus du SRAS.
- virologie : Infections à coronavirus, Syndrome respiratoire aigu sévère.
- Animaux, Humains, Immunité innée, Lignée cellulaire, Primates, Réplication virale, Tropisme viral.
English descriptors
- KwdEn :
- Animals, Cell Line, Coronavirus (immunology), Coronavirus (physiology), Coronavirus Infections (immunology), Coronavirus Infections (virology), Humans, Immunity, Innate, Interferon Regulatory Factor-3 (immunology), Interferon Type I (immunology), Primates, SARS Virus (immunology), SARS Virus (physiology), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (virology), Viral Tropism, Virus Replication.
- MESH :
- chemical , immunology : Interferon Regulatory Factor-3, Interferon Type I.
- immunology : Coronavirus, Coronavirus Infections, SARS Virus, Severe Acute Respiratory Syndrome.
- physiology : Coronavirus, SARS Virus.
- virology : Coronavirus Infections, Severe Acute Respiratory Syndrome.
- Animals, Cell Line, Humans, Immunity, Innate, Primates, Viral Tropism, Virus Replication.
Abstract
Infections with human coronavirus EMC (HCoV-EMC) are associated with severe pneumonia. We demonstrate that HCoV-EMC resembles severe acute respiratory syndrome coronavirus (SARS-CoV) in productively infecting primary and continuous cells of the human airways and in preventing the induction of interferon regulatory factor 3 (IRF-3)-mediated antiviral alpha/beta interferon (IFN-α/β) responses. However, HCoV-EMC was markedly more sensitive to the antiviral state established by ectopic IFN. Thus, HCoV-EMC can utilize a broad range of human cell substrates and suppress IFN induction, but it does not reach the IFN resistance of SARS-CoV.
Url:
DOI: 10.1128/JVI.03496-12
PubMed: 23449793
PubMed Central: 3624328
Affiliations:
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Le document en format XML
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(virology)</term><term>Humans</term><term>Immunity, Innate</term><term>Interferon Regulatory Factor-3 (immunology)</term><term>Interferon Type I (immunology)</term><term>Primates</term><term>SARS Virus (immunology)</term><term>SARS Virus (physiology)</term><term>Severe Acute Respiratory Syndrome (immunology)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Viral Tropism</term><term>Virus Replication</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Coronavirus (immunologie)</term><term>Coronavirus (physiologie)</term><term>Facteur-3 de régulation d'interféron (immunologie)</term><term>Humains</term><term>Immunité innée</term><term>Infections à coronavirus (immunologie)</term><term>Infections à coronavirus (virologie)</term><term>Interféron de type I (immunologie)</term><term>Lignée cellulaire</term><term>Primates</term><term>Réplication virale</term><term>Syndrome respiratoire aigu sévère (immunologie)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Tropisme viral</term><term>Virus du SRAS (immunologie)</term><term>Virus du SRAS (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Interferon Regulatory Factor-3</term><term>Interferon Type I</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Coronavirus</term><term>Facteur-3 de régulation d'interféron</term><term>Infections à coronavirus</term><term>Interféron de type I</term><term>Syndrome respiratoire aigu sévère</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Coronavirus</term><term>Coronavirus Infections</term><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Coronavirus</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Coronavirus</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Humans</term><term>Immunity, Innate</term><term>Primates</term><term>Viral Tropism</term><term>Virus Replication</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Immunité innée</term><term>Lignée cellulaire</term><term>Primates</term><term>Réplication virale</term><term>Tropisme viral</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Infections with human coronavirus EMC (HCoV-EMC) are associated with severe pneumonia. We demonstrate that HCoV-EMC resembles severe acute respiratory syndrome coronavirus (SARS-CoV) in productively infecting primary and continuous cells of the human airways and in preventing the induction of interferon regulatory factor 3 (IRF-3)-mediated antiviral alpha/beta interferon (IFN-α/β) responses. However, HCoV-EMC was markedly more sensitive to the antiviral state established by ectopic IFN. Thus, HCoV-EMC can utilize a broad range of human cell substrates and suppress IFN induction, but it does not reach the IFN resistance of SARS-CoV.</p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Becker, Stephan" sort="Becker, Stephan" uniqKey="Becker S" first="Stephan" last="Becker">Stephan Becker</name><name sortKey="Eickmann, Markus" sort="Eickmann, Markus" uniqKey="Eickmann M" first="Markus" last="Eickmann">Markus Eickmann</name><name sortKey="Matrosovich, Mikhail" sort="Matrosovich, Mikhail" uniqKey="Matrosovich M" first="Mikhail" last="Matrosovich">Mikhail Matrosovich</name><name sortKey="Spiegelberg, Larissa" sort="Spiegelberg, Larissa" uniqKey="Spiegelberg L" first="Larissa" last="Spiegelberg">Larissa Spiegelberg</name><name sortKey="Weber, Friedemann" sort="Weber, Friedemann" uniqKey="Weber F" first="Friedemann" last="Weber">Friedemann Weber</name><name sortKey="Weber, Michaela" sort="Weber, Michaela" uniqKey="Weber M" first="Michaela" last="Weber">Michaela Weber</name><name sortKey="Zaki, Ali Moh" sort="Zaki, Ali Moh" uniqKey="Zaki A" first="Ali Moh" last="Zaki">Ali Moh Zaki</name><name sortKey="Zielecki, Florian" sort="Zielecki, Florian" uniqKey="Zielecki F" first="Florian" last="Zielecki">Florian Zielecki</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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